The stream focuses on subjects like Physics, Chemistry, Biology, Computer Science, and Mathematics, preparing students for careers in engineering, medicine, and technology. The subjects combination of +2 science at Manaslu World College is as follows:
1. Compulsory Subjects
| Grade XI | Grade XII |
| Nepali | Nepali |
| English | English |
| Account | Account |
| Mathematics | Mathematics |
2. Optional Subjects
| Grade XI | Grade XII |
| Physics | Physics |
| Chemistry | Chemistry |
| Biology/Computer Science | Biology/Computer Science |
